Understanding How Bacteria Form Multicellular Biofilm Communities on Surfaces: The Role of C-Di-GMP as a Potent Biofilm Activator

Grant number: DP130100957 | Funding period: 2013 - 2015

Completed

Abstract

Bacteria usually exist as multicellular communities called biofilms when attached to surfaces, frequently to the detriment of the environment, industry and health. This project will explore the strategies bacteria use to switch from living as free-floating, individual cells to forming biofilms by studying how bacteria 'switch on' their biofilm genes.

Related publications (4)

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Biofilm formation by Klebsiella pneumoniae is mediated by the type 3 fimbriae Mrk, and regulated by MrkH and 3’,5’-cyclic diguanyl..

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Role of Capsular Polysaccharides in Biofilm Formation: An AFM Nanomechanics Study

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Positive autoregulation of mrkHI by the cyclic Di-GMP-dependent MrkH protein in the biofilm regulatory circuit of Klebsiella pneumoniae

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Transcriptional activation of the mrkA promoter of the Klebsiella pneumoniae type 3 fimbrial operon by the c-di-GMP-dependent MrkH protein

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University of Melbourne Researchers